JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human HSP22 Polyclonal (SPC-181)

BHA11907120
Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Antigen HSP22
Swissprot Q9UJY1
Accession Number NP_055180.1
Gene Id 26353
Target HSP22
Research Area Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Neurodegeneration, Neuroscience, Protein Trafficking
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100), IHC (1:100); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background HSP22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to HSP27. Similar to most other sHSPs, HSP22 is predominately transcribed in skeletal muscle and heart, as well as the placenta (1). HSP22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HSPB8 interacted preferentially with a triple aspartate form of HSP27 which mimics HSP27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type HSP27 (2). HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs (3). The chaperone-like activity is of great importance to the function of HSP22 in various processes including proliferation, apoptosis and macro autophagy (4). Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) (5).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~22kDa. Does not cross-react with HSP27 or alpha-crystallin.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), ICC/IF (1:100), IHC (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Kappe G., et al. (2001) Biochem Biophys Acta. 1520: 1-6.

2. Benndorf R., et al. (2001) J Biol Chem. 276: 26753-26761.

3. Sun X., et al. (2004) J Biol Chem. 279: 2394-2402.

4. Kim M.V., et al. (2004) Biochem Biophys Res Commun. 325: 649-652.

5. Wilhelmus M.M., et al. (2006) Acta Neuropathol. (Berl) 111: 139-149.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907120-1 SPC-181D Unconjugated 100 ul $282
Add to Cart
BHA11907120-2 SPC-181D-A390 ATTO 390 100 ul $337
Add to Cart
BHA11907120-3 SPC-181D-A488 ATTO 488 100 ul $336
Add to Cart
BHA11907120-4 SPC-181D-A594 ATTO 594 100 ul $336
Add to Cart
BHA11907120-5 SPC-181D-APC APC 100 ul $335
Add to Cart
BHA11907120-6 SPC-181D-BI Biotin 100 ul $332
Add to Cart
BHA11907120-7 SPC-181D-FITC FITC 100 ul $326
Add to Cart
BHA11907120-8 SPC-181D-HRP HRP 100 ul $322
Add to Cart
BHA11907120-9 SPC-181D-PCP PerCP 100 ul $335
Add to Cart
BHA11907120-10 SPC-181D-RPE RPE 100 ul $333
Add to Cart
BHA11907120-11 SPC-181S Unconjugated 12 ul $45
Add to Cart