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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human Beclin 1 Polyclonal (SPC-601)

SKU : BHA11908014

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-601, SPC-601D, SPC-601D-A390, SPC-601D-A488, SPC-601D-A594, SPC-601D-APC, SPC-601D-BI, SPC-601D-FITC, SPC-601D-HRP, SPC-601D-PCP, SPC-601D-RPE, SPC-601S
Immunogen Species	Human
Alternative Names	APG6 Antibody, BCL-2 interacting protein beclin Antibody, Beclin 1 autophagy related Antibody, BECN1 Antibody, BECN1_HUMAN Antibody, GT197 Antibody, VPS30 Antibody
Categories	Antibodies
Cellular Localization	Golgi apparatus, Trans-Golgi network membrane, Mitochondrion membrane, Cytoplasmic vesicle, Cytoplasm, Endosome, Endoplasmic reticulum membrane, Mitochondrion, Autophagosome
Certificate Of Analysis	A 1:1000 dilution of SPC-601 was sufficient for detection of Beclin1 on 293T lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Beclin 1 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen Region	Synthetic peptide from the C-terminus of human Beclin 1
Launch Date	2015/10/01
Net Weight (g)	0.1
Reactivity	Human, Rat
Species Reactivity Medium	Rat, Human

Antigen	Beclin 1
Swissprot	Q14457
Accession Number	NP_001300927.1
Gene Id	8678
Research Area	Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Cancer, Tumor suppressors, Autophagy, Cancer Metabolism

Concentration	1 mg/ml
Purification	Peptide Affinity Purified
Scientific Background	Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an inportant role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent train of Sindbis virus (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Predicted molecular weight at ~51kDa.
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Dilution	WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.

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Combination SKU	Supplier No.	Size	Conjugate	Your price	Quantity
BHA11908014-1	SPC-601D	100 ug	Unconjugated	$338		Add to Cart
BHA11908014-2	SPC-601D-A390	100 ug	ATTO 390	$393		Add to Cart
BHA11908014-3	SPC-601D-A488	100 ug	ATTO 488	$392		Add to Cart
BHA11908014-4	SPC-601D-A594	100 ug	ATTO 594	$392		Add to Cart
BHA11908014-5	SPC-601D-APC	100 ug	APC	$391		Add to Cart
BHA11908014-6	SPC-601D-BI	100 ug	Biotin	$388		Add to Cart
BHA11908014-7	SPC-601D-FITC	100 ug	FITC	$383		Add to Cart
BHA11908014-8	SPC-601D-HRP	100 ug	HRP	$378		Add to Cart
BHA11908014-9	SPC-601D-PCP	100 ug	PerCP	$391		Add to Cart
BHA11908014-10	SPC-601D-RPE	100 ug	RPE	$389		Add to Cart
BHA11908014-11	SPC-601S	12 ug	Unconjugated	$45		Add to Cart

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