Amyloid Fibrils (OC)

Mfr.No.	SPC-507, SPC-507D, SPC-507D-A390, SPC-507D-A488, SPC-507D-A594, SPC-507D-APC, SPC-507D-BI, SPC-507D-FITC, SPC-507D-HRP, SPC-507D-PCP, SPC-507D-RPE, SPC-507S
Immunogen Species	Human
Alternative Names	OC Antibody, Fibrils Antibody, Amyloid Oligomer aß Antibody, A11 Antibody, Amyloid beta A4 protein Antibody, ABPP Antibody, APPI Antibody, Alzheimer disease amyloid protein Antibody, Cerebral vascular amyloid peptide Antibody, PreA4 Antibody, Protease nexin-II Antibody, APP Antibody, A4 Antibody, AD Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	A 1:1000 dilution of SPC-507 was sufficient for detection of amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Amyloid Fibrils (OC) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Fibrils prepared from human amyloid beta 42 peptide, Homo Sapiens (Human)
Immunogen Region	Fibrils prepared from human amyloid beta 42 peptide
Launch Date	2012/01/13
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Antigen	Amyloid Fibrils
Target	Amyloid
Research Area	Amyloid, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Neuroscience

Buffer	PBS, 50% glycerol, 0.09% sodium azide
Dilutions	WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, IHC, DB, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP ; ELISA ; DB
Dilution	WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907976-1	SPC-507D	Unconjugated	100 ul	$324	Add to Cart
BHA11907976-2	SPC-507D-A390	ATTO 390	100 ul	$379	Add to Cart
BHA11907976-3	SPC-507D-A488	ATTO 488	100 ul	$378	Add to Cart
BHA11907976-4	SPC-507D-A594	ATTO 594	100 ul	$378	Add to Cart
BHA11907976-5	SPC-507D-APC	APC	100 ul	$377	Add to Cart
BHA11907976-6	SPC-507D-BI	Biotin	100 ul	$373	Add to Cart
BHA11907976-7	SPC-507D-FITC	FITC	100 ul	$368	Add to Cart
BHA11907976-8	SPC-507D-HRP	HRP	100 ul	$363	Add to Cart
BHA11907976-9	SPC-507D-PCP	PerCP	100 ul	$377	Add to Cart
BHA11907976-10	SPC-507D-RPE	RPE	100 ul	$374	Add to Cart
BHA11907976-11	SPC-507S	Unconjugated	12 ul	$45	Add to Cart

Rabbit Anti-Human Amyloid Fibrils (OC) Polyclonal (SPC-507)