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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human Alpha Synuclein pSer129 Polyclonal (SPC-742)

BHA11909914
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Email
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Antigen Alpha Synuclein
Swissprot P37840
Accession Number NP_000336.1
Gene Id 6622
Target Alpha Synuclein pSer129
Research Area Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Buffer PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration 0.5mg/mL
Dilutions WB (1:1000); IHC (1:500); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Highly expressed in brain (presynaptic nerve terminals) but is also expressed in low concentrations in all tissues examined except in liver.
Scientific Background Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4).
SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Alpha synuclein phosphorylated at serine 129 constitutes 90% of the alpha synuclein found in Lewy bodies (7, 8).
Shipping Temperature Blue Ice or 4°C
Specificity Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein. Detects bands at 100, 75, 45, 15 kDa. Bands above 15 kDa are oligomers.
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, IHC, WB, ICC/IF
Description WB ; ELISA ; IHC
Dilution WB (1:1000); ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).

2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.

3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.

4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.

5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.

6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

7. Fujiwara H., et al. (2002) Nat Cell Biol. 4(2):160-4.

8. Anderson J.P., et al. (2006) J Biol Chem. 281(40):29739-52.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11909914-1 SPC-742D Unconjugated 100 ul $417
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BHA11909914-2 SPC-742D-A390 ATTO 390 100 ul $472
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BHA11909914-3 SPC-742D-A488 ATTO 488 100 ul $471
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BHA11909914-4 SPC-742D-A594 ATTO 594 100 ul $471
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BHA11909914-5 SPC-742D-APC APC 100 ul $470
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BHA11909914-6 SPC-742D-BI Biotin 100 ul $467
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BHA11909914-7 SPC-742D-FITC FITC 100 ul $462
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BHA11909914-8 SPC-742D-HRP HRP 100 ul $458
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BHA11909914-9 SPC-742D-PCP PerCP 100 ul $470
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BHA11909914-10 SPC-742D-RPE RPE 100 ul $468
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BHA11909914-11 SPC-742S Unconjugated 12 ul $45
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