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Home / Primary Antibodies / Polyclonal Antibodies

phospho-beta-Catenin Antibody (pS33/37)

SKU : BHA17102567

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NSJ Bioreagents

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Mfr.No.	F53961, F53961-0.05ML, F53961-0.2ML
Clonality	Polyclonal
Description	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to amino acids surrounding pS33 and pS37 from the human protein was used as the immunogen for the phospho-beta-Catenin antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	Beta Catenin
Uniprot	P35222
Gene Id	1499

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the phospho-beta-Catenin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Dilution	Western blot: 1:500-1000

Product Manual	Data Sheet

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