Mouse Anti-Rat Nav beta 3 Sodium Channel Monoclonal IgG2B

Mfr.No.	SMC-490, SMC-490D, SMC-490D-A390, SMC-490D-A488, SMC-490D-A594, SMC-490D-APC, SMC-490D-BI, SMC-490D-FITC, SMC-490D-HRP, SMC-490D-PCP, SMC-490D-RPE, SMC-490S
Immunogen Species	Rat
Alternative Names	Sodium channel subunit beta-3 Antibody, Scn3b Antibody, KIAA1158 Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	A 1:100 dilution of SMC-490 was sufficient for detection of NavBeta3 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat Nav beta 3 Monoclonal IgG2B
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1-215 (full-length) of rat NavBeta3, Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
Isotype	IgG2B
Launch Date	2015/03/10
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	NaVbeta3
Swissprot	Q9JK00
Accession Number	NP_620797.1
Gene Id	245956
Target	NaVbeta3
Clone No	S396-29
Research Area	Ion Channels, Sodium Channels, Voltage-Gated Sodium Channels, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Genes and mapped phenotypes. (n.d.). Retrieved March 26, 2015, from http://www.ncbi.nlm.nih.gov/gene/ term=Q9jK00 2. Qu Y., et al. (2001) Mol Cell Neurosci. 18(5): 570-580. 3. Ishikawa T., et al. (2013) Circ J. 77(4): 956-967.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11905179-1	SMC-490D	Unconjugated	100 ug	$337	Add to Cart
BHA11905179-2	SMC-490D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11905179-3	SMC-490D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11905179-4	SMC-490D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11905179-5	SMC-490D-APC	APC	100 ug	$390	Add to Cart
BHA11905179-6	SMC-490D-BI	Biotin	100 ug	$386	Add to Cart
BHA11905179-7	SMC-490D-FITC	FITC	100 ug	$381	Add to Cart
BHA11905179-8	SMC-490D-HRP	HRP	100 ug	$377	Add to Cart
BHA11905179-9	SMC-490D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11905179-10	SMC-490D-RPE	RPE	100 ug	$388	Add to Cart
BHA11905179-11	SMC-490S	Unconjugated	12 ug	$45	Add to Cart

Nav beta 3 Antibody, Clone N396/29 (SMC-490)