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Home / Primary Antibodies / Polyclonal Antibodies

lexA Antibody (CSB-PA363985HA01ENV)

SKU : BHA10525796

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA363985HA01ENV
Alternative Names	LexA repressor (EC 3.4.21.88), lexA, exrA spr tsl umuA
Categories	Primary Antibodies
Clonality	polyclonal
Description	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
Host	Rabbit
Immunogen	Recombinant Escherichia coli LexA repressor protein (1-202AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Escherichia coli
Regulatory	RUO
Relevance	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
Species	Escherichia Coli (Strain K12)

Antigen	lexA
Uniprot	P0A7C2
Database Links	KEGG:ecj:JW4003 STRING:316385.ECDH10B_4232
Function	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment
Protein Families	Peptidase S24 family
Research Area	Others

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:5000

Tested Application

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10525796	CSB-PA363985HA01ENV	50ug	$166		Add to Cart
BHA10525796	CSB-PA363985HA01ENV	100ug	$299		Add to Cart

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