Mouse Anti-Human LAR (PTPRF) Monoclonal IgG2a

Mfr.No.	SMC-443, SMC-443D, SMC-443D-A390, SMC-443D-A488, SMC-443D-A594, SMC-443D-APC, SMC-443D-BI, SMC-443D-FITC, SMC-443D-HRP, SMC-443D-PCP, SMC-443D-RPE, SMC-443S
Immunogen Species	Human
Alternative Names	FLJ43335 Antibody, FLJ45062 Antibody, FLJ45567 Antibody, LAR Antibody, LAR protein Antibody, LARFN5C Antibody, LARS Antibody, LCA homolog Antibody, Leukocyte antigen related (LAR) PTP receptor Antibody, Leukocyte antigen related Antibody, Leukocyte antigen related PTP receptor Antibody, Leukocyte antigen related tyrosine phosphatase Antibody, Leukocyte common antigen related Antibody, Protein Tyrosine Phosphatase Receptor Type F Antibody, Protein tyrosine phosphatase receptor type F polypeptide Antibody, PTPRF protein Antibody, Receptor linked phosphatase LAR Antibody, Receptor type tyrosine protein phosphatase F Antibody, Receptor type tyrosine protein phosphatase F precursor Antibody, Receptor-type tyrosine-protein phosphatase F Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	1 ug/ml of SMC-443 was sufficient for detection of LAR/PTPRF in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human LAR/PTPRF Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR. 97% identical in both rat and mouse. >80% identity with PTPRD and PTPRS. >50% identity with PTPRM and PTPRK., Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR. 97% identical in both rat and mouse. >80% identity with PTPRD and PTPRS. >50% identity with PTPRM and PTPRK.
Isotype	IgG2a
Launch Date	2013/10/28
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	LAR
Swissprot	P10586
Accession Number	NP_002831.2.
Gene Id	5792
Target	LAR
Clone No	S165-38
Research Area	Cell Signaling, Post-translational Modifications, Phosphorylation, Cell Markers, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	PTPRF or leukocyte common antigen-related protein (LAR) is a widely expressed protein tyrosine phosphatase with an extracellular receptor region that resembles a cell adhesion molecule. PTPRF removes phosphate group from beta-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function (1,2,3,4). Anti-PTPRF (C-terminal) antibody is specific for the extracellular and cytoplasmic subunits of human PTPRF (approx. 210, 150 and 85 kDa). Detection of the PTPRF bands by immunoblotting is specifically inhibited by the immunizing peptide.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~85kDa (full length protein is 210 kDa smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Streuli M. M., et al. (1992) EMBO Journal, 11(3), 897-907. 2. Mooney R.A. and C.M LeVea. (2003) Current Topics in Medicinal Chemistry, 3(7), 809-819. 3. Chagnon M.J., et al. (2004) Biochemistry and Cell Biology, 82(6), 664-675. 4. Ahmad F.F., and B.J. Goldstein (1997) Journal of Biological Chemistry, 272(1), 448-457.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904324-1	SMC-443D	Unconjugated	100 ug	$337	Add to Cart
BHA11904324-2	SMC-443D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11904324-3	SMC-443D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11904324-4	SMC-443D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11904324-5	SMC-443D-APC	APC	100 ug	$390	Add to Cart
BHA11904324-6	SMC-443D-BI	Biotin	100 ug	$386	Add to Cart
BHA11904324-7	SMC-443D-FITC	FITC	100 ug	$381	Add to Cart
BHA11904324-8	SMC-443D-HRP	HRP	100 ug	$377	Add to Cart
BHA11904324-9	SMC-443D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11904324-10	SMC-443D-RPE	RPE	100 ug	$388	Add to Cart
BHA11904324-11	SMC-443S	Unconjugated	12 ug	$45	Add to Cart

LAR Antibody, Clone N165/38 (SMC-443)

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