Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Host
Rabbit
Immunogen Region
A portion of amino acids 2424-2458 from the human protein was used as the immunogen for the IGF2R antibody.
Isotype
Rabbit Ig
Species Reactivity
Human
Uniprot
P11717
Format
Antigen affinity purified
Purity
Antigen affinity
Storage
Aliquot the IGF2R antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.