Mouse Anti-Human HSP47 Monoclonal IgG1 Kappa

Mfr.No.	SMC-203, SMC-203B, SMC-203B-A390, SMC-203B-A488, SMC-203B-A594, SMC-203B-APC, SMC-203B-BI, SMC-203B-FITC, SMC-203B-HRP, SMC-203B-PCP, SMC-203B-RPE, SMC-203S
Immunogen Species	Human
Alternative Names	SerpinH1 Antibody, Colligin Antibody, Gp46 Antibody, serine proteinase inhibitor Antibody, cysteine proteinase inhibitor Antibody, collagen binding protein Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Endoplasmic Reticulum Lumen
Certificate Of Analysis	1 ug/ml of SMC-203 was sufficient for detection of HSP47 in 20 ug of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human HSP47 Monoclonal IgG1 Kappa
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Human HSP47, full length, Homo Sapiens (Human)
Immunogen Region	Human HSP47, full length
Isotype	IgG1 Kappa
Launch Date	2013/02/20
Net Weight (g)	0.2
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Antigen	HSP47
Swissprot	P50454.2
Accession Number	NP_001193943
Gene Id	871
Target	HSP47
Clone No	1C4-1A6
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1). The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 47kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Razzaque MS., Taquchi T., (1999) Histol Histopathol. 14 (4): 1999-212. 2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41. 3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11901624-1	SMC-203B	Unconjugated	200 ug	$370	Add to Cart
BHA11901624-2	SMC-203B-A390	ATTO 390	200 ug	$474	Add to Cart
BHA11901624-3	SMC-203B-A488	ATTO 488	200 ug	$471	Add to Cart
BHA11901624-4	SMC-203B-A594	ATTO 594	200 ug	$471	Add to Cart
BHA11901624-5	SMC-203B-APC	APC	200 ug	$470	Add to Cart
BHA11901624-6	SMC-203B-BI	Biotin	200 ug	$461	Add to Cart
BHA11901624-7	SMC-203B-FITC	FITC	200 ug	$453	Add to Cart
BHA11901624-8	SMC-203B-HRP	HRP	200 ug	$447	Add to Cart
BHA11901624-9	SMC-203B-PCP	PerCP	200 ug	$470	Add to Cart
BHA11901624-10	SMC-203B-RPE	RPE	200 ug	$463	Add to Cart
BHA11901624-11	SMC-203S	Unconjugated	12 ug	$45	Add to Cart

HSP47 Antibody, Clone 1C4-1A6 (SMC-203)