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Home / Primary Antibodies / Monoclonal Antibodies

HIF1a antibody

SKU : BHA10809929

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Mfr.No.	FNab09940
Background	Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256, .PMID: 7539918).
Clonality	monoclonal
Host	Mouse
Immunogen	hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Immunogen Region	hypoXia inducible factor 1, alpha subunit(basic heliX-loop-heliX transcription factor)
Isotype	IgG1
Molecular Weight	120 kDa
Reactivity	Human
Recommended Dilution	WB: 1:1000-1:10000; IF: 1:50-1:200
Synonyms	BHLHE78, MOP1, PASD8

Uniprot	Q16665
Gene Id	3091
Clone No	5H12
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Stem Cells, Neuroscience

Form	liquid
Purification	protein A+G purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:1000-1:10000; IF: 1:50-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09940.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809929	FNab09940	100ug	$280		Add to Cart

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