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Home / Primary Antibodies

HER2 Monoclonal Antibody

SKU : BHA13715094

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABM0030
Background	ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Erb-b2 receptor tyrosine kinase 2 has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of ERBB2 has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized
Clonality	Monoclonal
Formulation	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Host	Mouse
Immunogen	Synthetic Peptide
Isotype	Mouse IgG1
Reactivity	Human

Gene Id	2064

Concentration	1 mg/ml
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Storage Buffer	PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol

Applications	Protein General Reagents

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715094	ABM0030	100ul	$229		Add to Cart

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