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Home / Primary Antibodies / Polyclonal Antibodies

Guinea pig Anti-KCNN2 (KCa2.2, SK2) Antibody

SKU : BHA21300957

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Alomone Labs

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Mfr.No.	APC-028-GP, APC-028-GP-CF_0.2 ml, APC-028-GP_0.2 ml, APC-028-GP_25 mcl, APC-028-GP_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	KCa2.2 (KCNN2, SK2) is a member of the Ca2+-activated K+ channel family with small conductance that includes KCa2.1 (KCNN1, SK1) and KCa2.3 (KCNN3, SK3). The channel is voltage insensitive and is activated by intracellular Ca2+ in the submicromolar range. It has, though, a similar topology to that of voltage-dependent K+ channels (KV channels), that is six transmembrane domains and intracellular N- and C-termini. The functional channel of all the KCa2 family members is a multimeric protein composed of four pore-forming subunits.KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open the channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the least sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity.KCa2.2 is predominantly expressed in the nervous system although expression in endothelial cells, heart and liver has been described.KCa2.2 is known to be involved in the regulation of neuronal excitability. They do so mainly via a phenomenon known as after hyperpolarization in which KCa2 channels open in response to increased intracellular Ca2+ concentrations that result from the entry of extracellular Ca2+ through voltage-dependent Ca2+ channels during action potentials. In this way, KCa2 channels effectively form a Ca2+-mediated feedback loop.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat KCNN2 channel. Guinea pig Anti-KCNN2 (KCa2.2, SK2) Antibody (#APC-028-GP, formerly AGP-045) can be used in western blot analysis. It has been designed to recognize KCNN2 from human, rat and mouse samples. The antigen used to immunize guinea pigs is the same as Anti-KCNN2 (KCa2.2, SK2) Antibody (#APC-028) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.
Formulation	PBS pH7.4
Host	Guinea Pig
Immunogen Region	Intracellular, C-terminal domain
Isotype	Guinea pig total IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	SKCa2, Small conductance calcium-activated potassium channel protein 2, Apamin-sensitive small conductance Ca2+-dependent K+ channel
UNSPSC Code	41116161
Note	Homology: Mouse - 17/18 amino acid residues identical; human - 16/18 amino acid residues identical; chicken - 14/18 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC028 Specifictiy: KCNN2 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P70604
Gene Id	54262
Target	SKCa2, Small conductance calcium-activated potassium channel protein 2, Apamin-sensitive small conductance Ca2+-dependent K+ channel
Sequence	(C)ETQMENYDKHVTYNAERS, corresponding to amino acid residues 542-559 of rat KCNN2

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300957-1	APC-028-GP-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300957-2	APC-028-GP_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300957-3	APC-028-GP_25 mcl	25 mcl	$597		Add to Cart
BHA21300957-4	APC-028-GP_50 mcl	50 mcl	$697		Add to Cart

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