Mouse Anti-Rat GABA-A Receptor Alpha4 Monoclonal IgG1

Mfr.No.	SMC-489, SMC-489D, SMC-489D-A390, SMC-489D-A488, SMC-489D-A594, SMC-489D-APC, SMC-489D-BI, SMC-489D-FITC, SMC-489D-HRP, SMC-489D-PCP, SMC-489D-RPE, SMC-489S
Immunogen Species	Rat
Alternative Names	GABA A receptor subunit alpha 4 Antibody, GABRA4 Antibody, Gamma aminobutyric acid A receptor Alpha 4 Antibody
Categories	Antibodies
Cellular Localization	Cell Junction, Synapse, Postsynaptic Cell Membrane, Cell Membrane
Certificate Of Analysis	A 1:100 dilution of SMC-489 was sufficient for detection of GABA-A R, Alpha4 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat GABA-A Receptor Alpha4 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4, Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4
Isotype	IgG1
Launch Date	2015/03/10
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	GABA A Receptor
Swissprot	P28471
Accession Number	NP_542154.3
Gene Id	140675
Target	GABA A Receptor
Clone No	S398A-34
Research Area	Neurotransmitter Receptors, GABA Receptors, GABAA Receptors, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). GABA-A Receptor Alpha 4 is associated with epilepsy (3), and research suggests that alterations in GABA- A Receptors subtypes may be involved in the resistance to antiepileptic drugs (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602. 3. Grabenstatter H.L., et al. (2014) Epilepsia. 55(11): 1826-1833. 4. Bethmann K., Fritschy J.M., Brandt C., Loscher W. (2008) Neurbiol Dis. 31(2): 169-187.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11905160-1	SMC-489D	Unconjugated	100 ug	$337	Add to Cart
BHA11905160-2	SMC-489D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11905160-3	SMC-489D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11905160-4	SMC-489D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11905160-5	SMC-489D-APC	APC	100 ug	$390	Add to Cart
BHA11905160-6	SMC-489D-BI	Biotin	100 ug	$386	Add to Cart
BHA11905160-7	SMC-489D-FITC	FITC	100 ug	$381	Add to Cart
BHA11905160-8	SMC-489D-HRP	HRP	100 ug	$377	Add to Cart
BHA11905160-9	SMC-489D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11905160-10	SMC-489D-RPE	RPE	100 ug	$388	Add to Cart
BHA11905160-11	SMC-489S	Unconjugated	12 ug	$45	Add to Cart

GABAA Receptor Alpha 4 Antibody, Clone N398A/34 (SMC-489)