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Home / Primary Antibodies / Polyclonal Antibodies

Derlin 1 Antibody / DERL1

SKU : BHA17103458

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NSJ Bioreagents

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Mfr.No.	F54998, F54998-0.08ML, F54998-0.4ML
Clonality	Polyclonal
Description	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.
Isotype	Ig
Predicted Reactivity	Human, Mouse
Reactivity	Human, Mouse
Recombinant	No
Subcellular Location	Cytoplasmic

Antigen	DERL1
Uniprot	Q9BUN8

Format	Purified
Purification	Antigen affinity purified
Storage	Aliquot the Derlin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	FACS, IHC-P, WB
Dilution	Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE): 1:50-1:100, Western blot: 1:500-1:1000

Product Manual	Data Sheet

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