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Home / Primary Antibodies / Monoclonal Antibodies

Clusterin

SKU : BHA15100462

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Mfr.No.	AMB33-5M
Clonality	Monoclonal
Description	Clusterin, also known as Apolipoprotein J, Sulfated Glycoprotein 2 (SGP-2), TRPM-2, and SP-40,40, is a secreted multifunctional glycoprotein that is expressed ubiquitously in most tissues. The main function of clusterin is to interact and stabilize stress-induced proteins to prevent them from precipitation. Additionally, it participates in the control of cell proliferation, apoptosis, and carcinogenesis. The subcellular distribution of multiple isoforms leads to the diversity of clusterin functions. Clusterin is secreted as a disulfide-linked heterodimer of alpha and beta chains and circulates as a component of high density lipoprotein (HDL) particles. Clusterin exerts tissue protective functions in atherosclerosis and Alzheimers disease by binding and neutralizing non-oxidatively modified LDL reduces cytotoxicity and beta-amyloid fibrils, respectively. Increased circulating levels of Clusterin enhance tumor aggressiveness by inhibiting apoptosis and by promoting epithelial to mesenchymal transition. Clusterin expression is observed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development.
Host	Mouse
Isotype	IgG2a
Reactivity	Human
Species	Mouse

Clone No	A-9
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-50

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB33-5M	AMB33-5M	6 mL	$293		Add to Cart
AMB33-10M	AMB33-10M	100 tests - i6000	$548		Add to Cart
AXB33-50D	AXB33-50D	50 tests - Xmatrx	$308		Add to Cart
AXB33-YCD	AXB33-YCD	160 tests - Xmatrx	$751		Add to Cart
MUB33-UC	MUB33-UC	1ml Conc	$601		Add to Cart
MUB33-5UC	MUB33-5UC	0.5ml Conc	$420		Add to Cart

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