Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm(LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium(AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Clonality
polyclonal
Host
Rabbit
Immunogen
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Immunogen Region
Cbp/p300-interacting transactIVator, with Glu/Asp-rich carboXy-terminal domain, 2
Isotype
IgG
Molecular Weight
27 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
IHC: 1:50-1:200
Synonyms
CITED2, MRG 1, MRG1, MSG related protein 1, P35SRJ