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Home / Primary Antibodies / Monoclonal Antibodies

BCR-ABL

SKU : BHA15100329

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Mfr.No.	AM903-5M
Clonality	Monoclonal
Description	Translocation between chromosomes 9 and 22 lead to the formation of the Philadelphia chromosome which contain the BCR-ABL fusion gene found in most patients with Chronic Myeloid Leukemia (CML) and some patients with Acute Lymphoblastic leukemia (ALL) or Acute Myelogenous Leukemia (AML). The BCR-ABL oncoprotein possessing tyrosine kinase function is responsible for the pathogenesis of CML. Several domains of BCR-ABL protein coordinate, involve and contribute in the pathogenesis of CML. BCR-ABL aberrantly activates multiple signal pathways involving leukemic cell proliferation and survival. Besides GRB2 coupled RAS-MAPK and PI3K/AKT signal pathways, BCR-ABL also activates STAT5 and CRKL signal molecules.
Host	Mouse
Isotype	IgG
Reactivity	Human
Species	Mouse

Clone No	7C6
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-100

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM903-5M	AM903-5M	6 mL	$336		Add to Cart
AM903-10M	AM903-10M	100 tests - i6000	$620		Add to Cart
AX903-50D	AX903-50D	50 tests - Xmatrx	$348		Add to Cart
AX903-YCD	AX903-YCD	160 tests - Xmatrx	$849		Add to Cart
MU903-UC	MU903-UC	1ml Conc	$679		Add to Cart
MU903-5UC	MU903-5UC	0.5ml Conc	$475		Add to Cart

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