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Home / Primary Antibodies / Polyclonal Antibodies

ATG12 antibody

SKU : BHA10810334

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Mfr.No.	FNab10376
Background	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Clonality	polyclonal
Host	Rabbit
Immunogen	ATG12 autophagy related 12 homolog
Immunogen Region	ATG12 autophagy related 12 homolog(S. cereVIsiae)
Isotype	IgG
Molecular Weight	48-50kd
Reactivity	Human, Mouse
Recommended Dilution	IHC: 1:50-1:200
Synonyms	APG12, APG12L

Uniprot	O94817
Gene Id	9140
Research Area	Epigenetics, Immunology, Cardiovascular, Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	IHC: 1:50-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10376.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810334	FNab10376	100ug	$240		Add to Cart

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