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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ZWINT Antibody Picoband®

SKU : BHA21000923

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Mfr.No.	PB10018, PB10018-10ug, PB10018-Biotin, PB10018-Cy3, PB10018-Dylight488, PB10018-Dylight550, PB10018-Dylight594, PB10018-FITC, PB10018-HRP, PB10018-APC, PB10018-PE, PB10018-iFluor647, PB10018-carrier-free
Alternative Names	ZW10 interactor
Background	ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ZWINT Antibody Picoband® catalog # PB10018. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. .
Host	Rabbit
Immunogen Region	E.coli-derived human ZWINT recombinant protein (Position: Q29-Q249). Human ZWINT shares 58% and 57.1% amino acid (aa) sequence identity with mouse and rat ZWINT, respectively.
Isotype	Rabbit IgG
Molecular Weight	31 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	ZW10 interactor;ZW10-interacting protein 1;Zwint-1;ZWINT;
Tissue Specificity	Detected in all tissues tested.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O95229
Gene Id	11130
Gene Name	ZWINT
Sequence	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Localizes to kinetochores from late prophase to anaphase.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. "Entrez Gene: ZWINT ZW10 interactor". 2. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology 6 (11): 113541. 3. van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters 582 (19): 283842.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000923-1	PB10018	100 ug	-	$370		Add to Cart
BHA21000923-2	PB10018-10ug	10 ug	Sample	$99		Add to Cart
BHA21000923-3	PB10018-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000923-4	PB10018-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000923-5	PB10018-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000923-6	PB10018-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000923-7	PB10018-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000923-8	PB10018-FITC	100 ug	FITC	$570		Add to Cart
BHA21000923-9	PB10018-HRP	100 ug	HRP	$570		Add to Cart
BHA21000923-10	PB10018-APC	100 ug	APC	$670		Add to Cart
BHA21000923-11	PB10018-PE	100 ug	PE	$670		Add to Cart
BHA21000923-12	PB10018-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000923-13	PB10018-carrier-free	100 ug	carrier-free	$370		Add to Cart

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