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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ZnT1 (SLC30A1) Antibody

SKU : BHA21301344

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Alomone Labs

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Mfr.No.	AZT-011, AZT-011-CF_0.2 ml, AZT-011_0.2 ml, AZT-011_25 mcl, AZT-011_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	ZnT1 is a member of the SLC30 family of zinc transporters which promotes the influx of zinc ions into synaptic vesicles of glutamatergic neurons from the cytoplasm, intracellular organelles, and from the extracellular milieu.Zinc plays an essential role in many physiological and pathological conditions such as synaptic plasticity modulation, memory formation and nociception by regulating transmitter receptors and signal transduction pathways. Therefore zinc homeostasis is tightly regulated at the cellular and the organismal levels1,2.ZnT1 in mammals is localized primarily on the plasma membrane. Its role is to mediate zinc export to reduce intracellular zinc levels1. ZnT1 structure contains a PDZ I motif at the C-terminus and six transmembrane-spanning domains. There is also a (His-Gly)8 in the large intracellular loop between membrane-spanning regions 4 and 52,4.ZnT1 expression is ubiquitous and is detected in the intestine, kidney and liver. In the intestine the expression is regional, being much greater in the duodenum and jejunum and in villus versus crypt cells.The mechanism of ZnT1 regulation is under control of the zinc-responsive transcription factor MTF-11. Research shows that homozygous knockout of the ZnT1 gene is lethal to the foetus3.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat Zinc transporter 1. Anti-ZnT1 (SLC30A1) Antibody (#AZT-011) can be used in western blot and immunohistochemistry applications. It has been designed to recognize ZnT1 from mouse, rat, and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Intracellular, C-terminus
Isotype	Rabbit IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Zinc transporter 1, ZRC 1
UNSPSC Code	41116161
Note	Homology: Mouse, human - 12/13 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-ZT011 Specifictiy: SLC30A1 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q62720
Gene Id	58976
Target	Zinc transporter 1, ZRC 1
Sequence	(C)ENLEKKPRRTKAE, corresponding to amino acid residues 473-485 of rat ZnT1

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	1:300

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301344-1	AZT-011-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301344-2	AZT-011_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301344-3	AZT-011_25 mcl	25 mcl	$597		Add to Cart
BHA21301344-4	AZT-011_50 mcl	50 mcl	$697		Add to Cart

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