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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Zinc finger protein GLI2 GLI2 Antibody Picoband®

SKU : BHA21002223

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Mfr.No.	A00701-5, A00701-5-10ug, A00701-5-Biotin, A00701-5-Cy3, A00701-5-Dylight488, A00701-5-Dylight550, A00701-5-Dylight594, A00701-5-FITC, A00701-5-HRP, A00701-5-APC, A00701-5-PE, A00701-5-iFluor647, A00701-5-carrier-free
Alternative Names	GLI family zinc finger 2
Background	GLI2 (Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel (Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes; thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al. refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al. showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Zinc finger protein GLI2 GLI2 Antibody catalog # A00701-5. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Required for normal embryonic developmen
Host	Rabbit
Immunogen Region	E.coli-derived human GLI2 recombinant protein (Position: K721-D1457).
Isotype	Rabbit IgG
Molecular Weight	210 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Zinc finger protein GLI2; GLI family zinc finger protein 2; Tax helper protein; GLI2; THP
Tissue Specificity	Expressed in breast cancers. Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines. Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P10070
Gene Id	2736
Gene Name	GLI2
Subcellular Location	Nucleus. Cytoplasm. Cilium.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Bertolacini, C. D. P., Ribeiro-Bicudo, L. A., Petrin, A., Richieri-Costa, A., Murray, J. C. Clinical findings in patients with GLI2 mutations--phenotypic variability. Clin. Genet. 81: 70-75, 2012.<br /><br />2. Matsumoto, N., Fujimoto, M., Kato, R., Niikawa, N. Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization. Genomics 36: 220-221, 1996.<br /><br />3. Roessler, E., Ermilov, A. N., Grange, D. K., Wang, A., Grachtchouk, M., Dlugosz, A. A., Muenke, M. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum. Molec. Genet. 14: 2181-2188, 2005.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002223-1	A00701-5	-	100 ug	$370		Add to Cart
BHA21002223-2	A00701-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21002223-3	A00701-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002223-4	A00701-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002223-5	A00701-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002223-6	A00701-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002223-7	A00701-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002223-8	A00701-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21002223-9	A00701-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21002223-10	A00701-5-APC	APC	100 ug	$670		Add to Cart
BHA21002223-11	A00701-5-PE	PE	100 ug	$670		Add to Cart
BHA21002223-12	A00701-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002223-13	A00701-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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