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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Vitamin D Receptor/VDR Antibody Picoband®

SKU : BHA21007213

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Mfr.No.	PA1983, PA1983-10ug, PA1983-Biotin, PA1983-Cy3, PA1983-Dylight488, PA1983-Dylight550, PA1983-Dylight594, PA1983-FITC, PA1983-HRP, PA1983-APC, PA1983-PE, PA1983-iFluor647, PA1983-carrier-free
Alternative Names	Vitamin D3 receptor
Background	VDR (Vitamin D Receptor), also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al. (1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al. (2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB (TFIIB). A natural polymorphic variant of VDR, termed F/M4 (missing a FokI restriction site), which lacks only the first 3 amino acids (including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length (f/M1) receptor. Shah et al. (2006) stated that the signaling and oncogenic activity of beta-catenin (CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Vitamin D Receptor/VDR Antibody catalog # PA1983. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histo
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human VDR, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	450 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Vitamin D3 receptor;VDR;1,25-dihydroxyvitamin D3 receptor;Nuclear receptor subfamily 1 group I member 1;VDR;NR1I1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P11473
Gene Name	VDR
Sequence	Belongs to the nuclear hormone receptor family. NR1 subfamily.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Jurutka, P. W., Remus, L. S., Whitfield, G. K., Thompson, P. D., Hsieh, J.-C., Zitzer, H., Tavakkoli, P., Galligan, M. A., Dang, H. T. L., Haussler, C. A., Haussler, M. R. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Molec. Endocr. 14: 401-420, 2000. <br /><br />2. Labuda, M., Ross, M. V., Fujiwara, T. M., Morgan, K., Ledbetter, D., Hughes, M. R., Glorieux, F. H. Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q.II(Abstract) Cytogenet. Cell Genet. 58: 1978, 1991.<br /><br />3. Shah, S., Islam, M. N., Dakshanamurthy, S., Rizvi, I., Rao, M., Herrell, R., Zinser, G., Valrance, M., Aranda, A., Moras, D., Norman, A., Welsh, J., Byers, S. W. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Molec. Cell 21: 799-809, 2006. Note: Erratum: Molec. Cell 21: 148 only, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007213-1	PA1983	-	100 ug	$370		Add to Cart
BHA21007213-2	PA1983-10ug	Sample	10 ug	$99		Add to Cart
BHA21007213-3	PA1983-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007213-4	PA1983-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007213-5	PA1983-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007213-6	PA1983-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007213-7	PA1983-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007213-8	PA1983-FITC	FITC	100 ug	$570		Add to Cart
BHA21007213-9	PA1983-HRP	HRP	100 ug	$570		Add to Cart
BHA21007213-10	PA1983-APC	APC	100 ug	$670		Add to Cart
BHA21007213-11	PA1983-PE	PE	100 ug	$670		Add to Cart
BHA21007213-12	PA1983-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007213-13	PA1983-carrier-free	carrier-free	100 ug	$370		Add to Cart

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