Anti-undefined Antibody rSOX10,1074 Unconjugated BHA10208288

Mfr.No.	6663-MSM6-P1ABX
Alternative Names	DOM ; PCWH ; SOX10 ; SRY (sex determining region Y) box 10 ; SRY box containing gene 10 ; SRY related HMG box gene 10 ; Waardenburg syndrome type 2E (WS2E) ; WS4 ; Waardenburg syndrome type 4C (WS4C)
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	22q13.1
Clonality	monoclonal
Description	SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Host	Mouse
Immunogen	Recombinant fragment of human SOX10 protein (around aa 115-269) (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	HepG2 cells. Melanomas, breast carcinomas, gliomas.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P56693
Gene Id	6663
Clone No	rSOX10, 1074
Symbol	SOX10
Weight	49-58kDa

Buffer	200μg/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

0.5-1μg/ml for 30 minutes at RT

No Description Available.

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10208288	6663-MSM6-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody rSOX10,1074 Unconjugated BHA10208288

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