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Home / Primary Antibodies / Polyclonal Antibodies

Anti-UMOD Antibody Picoband®

SKU : BHA21002884

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Mfr.No.	A01303-2, A01303-2-10ug, A01303-2-Biotin, A01303-2-Cy3, A01303-2-Dylight488, A01303-2-Dylight550, A01303-2-Dylight594, A01303-2-FITC, A01303-2-HRP, A01303-2-APC, A01303-2-PE, A01303-2-iFluor647, A01303-2-carrier-free
Alternative Names	collagen, type XVIII, alpha 1
Background	Uromodulin (UMOD), also known as TammHorsfall protein (THP), is a glycoprotein that in humans is encoded by the UMOD gene. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alteative splicing of this gene results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-UMOD Antibody Picoband® catalog # A01303-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Host	Rabbit
Immunogen Region	E.coli-derived human UMOD recombinant protein (Position: E43-S618).
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Collagen alpha-1 (XVIII) chain; Endostatin; COL18A1
Tissue Specificity	Present in multiple organs with highest levels in liver, lung and kidney.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P07911
Gene Id	7369
Gene Name	UMOD
Subcellular Location	Secreted, extracellular space, extracellular matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat, Monkey<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Bachmann, S., Mutig, K., Bates, J., Welker, P., Geist, B., Gross, V., Luft, F. C., Alenina, N., Bader, M., Thiele, B. J., Prasadan, K., Raffi, H. S., Kumar, S. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am. J. Physiol. Renal Physiol. 288: F559-F567, 2005.<br /><br />2. Beascone, I., Janas, S., Ikehata, M., Trudu, M., Corbelli, A., Schaeffer, C., Rastaldi, M. P., Devuyst, O., Rampoldi, L. A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure. Hum. Molec. Genet. 19: 2998-3010, 2010.<br /><br />3. Dahan, K., Devuyst, O., Smaers, M., Vertommen, D., Loute, G., Poux, J. M., Viron, B., Jacquot, C., Gagnadoux, M. F., Chauveau, D., Buchler, M., Cochat, P., Cosyns, J. P., Mougenot, B., Rider, M. H., Antignac, C., Verellen-Dumoulin, C., Pirson, Y. A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J. Am. Soc. Nephrol. 14: 2883-2893, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002884-1	A01303-2	-	100 ug	$370		Add to Cart
BHA21002884-2	A01303-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002884-3	A01303-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002884-4	A01303-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002884-5	A01303-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002884-6	A01303-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002884-7	A01303-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002884-8	A01303-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002884-9	A01303-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002884-10	A01303-2-APC	APC	100 ug	$670		Add to Cart
BHA21002884-11	A01303-2-PE	PE	100 ug	$670		Add to Cart
BHA21002884-12	A01303-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002884-13	A01303-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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