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Home / Primary Antibodies

Anti-Tyrosine Hydroxylase Antibody

SKU : BHA10902503

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y075045
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.
Host	Rabbit
Immunogen	A synthetic peptide (SPRFIGRRQSLIEDARK) as part of human Tyrosine Hydroxylase (61-77) conjugated to KLH has been used as the immunogen. The peptide is homologous with the corresponding sequence derived from TH protein in rat (30-46).
Quantity	100 µl
Reactivity	Rat
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% sodium azide.
Concentration	1µg/ul
Description	Specificity: IHC on brain shows a pattern of staining specific for TH containing neurons.
Format	Liquid
Purity	Filter purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications	IHC
Description	A dilution of 1:2000 to 1: 5000 is recommended for this application. The optimal working dilution should be determined by the end user. This is a superb antibody for detection of tyrosine hydroxylase containing neurons exhibiting an intense labeling with a negligible background. This antiserum has proven extremely useful for staining of catecholaminergic neurons. It stains nicely and intensely dendritic processes and fine nerve terminals., IHC

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SKU	Supplier No.	Size	Your price	Quantity
BHA10902503	Y075045	100 ul	$802.50		Add to Cart

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