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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TRAF3 Antibody Picoband®

SKU : BHA21007233

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Mfr.No.	PA2008, PA2008-10ug, PA2008-Biotin, PA2008-Cy3, PA2008-Dylight488, PA2008-Dylight550, PA2008-Dylight594, PA2008-FITC, PA2008-HRP, PA2008-APC, PA2008-PE, PA2008-iFluor647, PA2008-carrier-free
Alternative Names	TNF receptor-associated factor 3
Background	TRAF3 (TNF Receptor-Associated Factor 3), also called LAP1, CAP1, CRAF1 or CD40BP, is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. Gross (2012) mapped the TRAF3 gene to chromosome 14q32.32 based on an alignment of the TRAF3 sequence with the genomic sequence (GRCh37). Dadgostar et al. (2003) determined that the coiled-coil domain of mouse T3jam interacted with the isoleucine zipper domain of Traf3. Oganesyan et al. (2006) demonstrated that cells lacking TRAF3 are defective in type I interferon responses activated by several different Toll-like receptors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TRAF3 Antibody catalog # PA2008. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isot
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TRAF3, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	TNF receptor-associated factor 3;6.3.2.-;CAP-1;CD40 receptor-associated factor 1;CRAF1;CD40-binding protein;CD40BP;LMP1-associated protein 1;LAP1;TRAF3;CAP1, CRAF1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13114
Gene Name	TRAF3
Sequence	Belongs to the TNF receptor-associated factor family. A subfamily.
Subcellular Location	Cytoplasm . Endosome . Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Dadgostar, H., Doyle, S. E., Shahangian, A., Garcia, D. E., Cheng, G. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. FEBS Lett. 553: 403-407, 2003.<br /><br />2. Gross, M. B. Personal Communication. Baltimore, Md. 10/5/2012.<br /><br />3. Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zaegar, B., Perry, A., Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439: 208-211, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007233-1	PA2008	-	100 ug	$370		Add to Cart
BHA21007233-2	PA2008-10ug	Sample	10 ug	$99		Add to Cart
BHA21007233-3	PA2008-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007233-4	PA2008-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007233-5	PA2008-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007233-6	PA2008-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007233-7	PA2008-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007233-8	PA2008-FITC	FITC	100 ug	$570		Add to Cart
BHA21007233-9	PA2008-HRP	HRP	100 ug	$570		Add to Cart
BHA21007233-10	PA2008-APC	APC	100 ug	$670		Add to Cart
BHA21007233-11	PA2008-PE	PE	100 ug	$670		Add to Cart
BHA21007233-12	PA2008-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007233-13	PA2008-carrier-free	carrier-free	100 ug	$370		Add to Cart

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