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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TORC2/CRTC2 Antibody Picoband®

SKU : BHA21007217

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Mfr.No.	PA1988, PA1988-10ug, PA1988-Biotin, PA1988-Cy3, PA1988-Dylight488, PA1988-Dylight550, PA1988-Dylight594, PA1988-FITC, PA1988-HRP, PA1988-APC, PA1988-PE, PA1988-iFluor647, PA1988-carrier-free
Alternative Names	CREB-regulated transcription coactivator 2
Background	CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TORC2/CRTC2 Antibody catalog # PA1988. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently o
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TORC2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	CREB-regulated transcription coactivator 2;Transducer of regulated cAMP response element-binding protein 2;TORC-2;Transducer of CREB protein 2;CRTC2;TORC2;
Tissue Specificity	Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q53ET0
Gene Name	CRTC2
Sequence	Belongs to the TORC family.
Subcellular Location	Cytoplasm. Nucleus. Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D., Chi, G.-W., McWhinnie, E., and 9 others. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Nat. Acad. Sci. 100: 12147-12152, 2003. <br /><br />2. Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., Yates, J., III, Olefsky, J., Guarente, L., Montminy, M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273, 2008. <br /><br />3. Wang, Y., Vera, L., Fischer, W. H., Montminy, M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460: 534-537, 2009.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007217-1	PA1988	-	100 ug	$370		Add to Cart
BHA21007217-2	PA1988-10ug	Sample	10 ug	$99		Add to Cart
BHA21007217-3	PA1988-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007217-4	PA1988-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007217-5	PA1988-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007217-6	PA1988-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007217-7	PA1988-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007217-8	PA1988-FITC	FITC	100 ug	$570		Add to Cart
BHA21007217-9	PA1988-HRP	HRP	100 ug	$570		Add to Cart
BHA21007217-10	PA1988-APC	APC	100 ug	$670		Add to Cart
BHA21007217-11	PA1988-PE	PE	100 ug	$670		Add to Cart
BHA21007217-12	PA1988-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007217-13	PA1988-carrier-free	carrier-free	100 ug	$370		Add to Cart

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