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Home / Antibodies

Anti-TOP2B Antibody

SKU : BHA10902803

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y058353
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Clonality	polyclonal
Description	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
Host	Rabbit
Immunogen	Rabbit polyclonal TOP2B antibody was raised against a 15 amino acid peptide from near the C terminal residues of human TOP2B.
Isotype	IgG
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

IHC, ELISA

Description

For research use only
Peptide ELISA titer: 1:1,000-1:10,000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end use., IHC ; ELISA

Dilution

ELISA	1:1,000-1:10,000
IHC	1:50-200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10902803	Y058353	100 ul	$217.50		Add to Cart

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