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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TNF beta/LTA Antibody Picoband®

SKU : BHA21006744

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Mfr.No.	PA1361, PA1361-10ug, PA1361-Biotin, PA1361-Cy3, PA1361-Dylight488, PA1361-Dylight550, PA1361-Dylight594, PA1361-FITC, PA1361-HRP, PA1361-APC, PA1361-PE, PA1361-iFluor647, PA1361-carrier-free
Alternative Names	Lymphotoxin-alpha
Background	Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al. (1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TNF beta/LTA Antibody catalog # PA1361. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TNF beta, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	6 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Lymphotoxin-alpha;LT-alpha;TNF-beta;Tumor necrosis factor ligand superfamily member 1;LTA;TNFB, TNFSF1;
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P01374
Gene Name	LTA
Sequence	Belongs to the tumor necrosis factor family.
Subcellular Location	Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". The immune system (2nd ed.). New York: Garland Science. p. 172.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006744-1	PA1361	-	100 ug	$370		Add to Cart
BHA21006744-2	PA1361-10ug	Sample	10 ug	$99		Add to Cart
BHA21006744-3	PA1361-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006744-4	PA1361-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006744-5	PA1361-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006744-6	PA1361-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006744-7	PA1361-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006744-8	PA1361-FITC	FITC	100 ug	$570		Add to Cart
BHA21006744-9	PA1361-HRP	HRP	100 ug	$570		Add to Cart
BHA21006744-10	PA1361-APC	APC	100 ug	$670		Add to Cart
BHA21006744-11	PA1361-PE	PE	100 ug	$670		Add to Cart
BHA21006744-12	PA1361-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006744-13	PA1361-carrier-free	carrier-free	100 ug	$370		Add to Cart

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