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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Tight junction protein ZO-2 TJP2 Antibody Picoband®

SKU : BHA21007205

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Mfr.No.	PA1971, PA1971-10ug, PA1971-Biotin, PA1971-Cy3, PA1971-Dylight488, PA1971-Dylight550, PA1971-Dylight594, PA1971-FITC, PA1971-HRP, PA1971-APC, PA1971-PE, PA1971-iFluor647, PA1971-carrier-free
Alternative Names	Tight junction protein ZO-2
Background	TJP2 (Tight Junction Protein 2), also known as Zona Occludens 2 or ZO2, is a protein that in humans is encoded by the TJP2 gene. Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. Duclos et al. (1994) mapped the TJP2 gene telomeric to the Friedreich ataxia critical region on chromosome 9q13-q21. TJP2 lies about 70 kb centromeric to the X123 gene and is transcribed in the centromere-to-telomere ion. Using in vitro assays and immunoprecipitation studies, Itoh et al. (1999) showed that the mouse Tjp1, Tjp2, and Tjp3 PDZ1 domains interacted with the C-terminal cytoplasmic domains of Cldn1 through Cldn8. In the mouse inner ear, Walsh et al. (2010) found that Tjp2 expression decreased rapidly between E16.5 and age 1 week to a level in adult mice that was approximately 50% of the level at birth (P0).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Tight junction protein ZO-2 TJP2 Antibody catalog # PA1971. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a role in tight junctions and adherens junctions.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse TJP2, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tight junction protein ZO-2;Tight junction protein 2;Zona occludens protein 2;Zonula occludens protein 2;Tjp2;Zo2;
Tissue Specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.01mg NaN3.

Uniprot	Q9Z0U1
Gene Name	TJP2
Sequence	Belongs to the MAGUK family.
Subcellular Location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus . Cell junction, tight junction . Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat, By Heat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br>

Reference	1. Duclos, F., Rodius, F., Wrogemann, K., Mandel, J.-L., Koenig, M. The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb. Hum. Molec. Genet. 3: 909-914, 1994.<br /><br />2. Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., Tsukita, S. binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 147: 1351-1363, 1999.<br /><br />3. Walsh, T., Pierce, S. B., Lenz, D. R., Brownstein, Z., Dagan-Rosenfeld, O., Shahin, H., Roeb, W., McCarthy, S., Nord, A. S., Gordon, C. R., Ben-Neriah, Z., Sebat, J., Kanaan, M., Lee, M. K., Frydman, M., King, M.-C., Avraham, K. B. Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am. J. Hum. Genet. 87: 101-109, 2010.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007205-1	PA1971	-	100 ug	$370		Add to Cart
BHA21007205-2	PA1971-10ug	Sample	10 ug	$99		Add to Cart
BHA21007205-3	PA1971-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007205-4	PA1971-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007205-5	PA1971-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007205-6	PA1971-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007205-7	PA1971-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007205-8	PA1971-FITC	FITC	100 ug	$570		Add to Cart
BHA21007205-9	PA1971-HRP	HRP	100 ug	$570		Add to Cart
BHA21007205-10	PA1971-APC	APC	100 ug	$670		Add to Cart
BHA21007205-11	PA1971-PE	PE	100 ug	$670		Add to Cart
BHA21007205-12	PA1971-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007205-13	PA1971-carrier-free	carrier-free	100 ug	$370		Add to Cart

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