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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SynCAM/CADM1 Antibody Picoband®

SKU : BHA21000038

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Mfr.No.	PB9136, PB9136-10ug, PB9136-Biotin, PB9136-Cy3, PB9136-Dylight488, PB9136-Dylight550, PB9136-Dylight594, PB9136-FITC, PB9136-HRP, PB9136-APC, PB9136-PE, PB9136-iFluor647, PB9136-carrier-free
Alternative Names	Cell adhesion molecule 1
Background	Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. This gene is also known as IGSF4, SYNCAM or TSLC1, and it is mapped to 11q23.3. CADM1 functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of CADM1 in neurons inhibited synapse assembly. Conversely, expression of full-length CADM1 in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SynCAM/CADM1 Antibody Picoband® catalog # PB9136. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates homophilic cell-cell adhesion in a Ca (2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interactio
Host	Rabbit
Immunogen Region	E.coli-derived human SynCAM recombinant protein (Position: Q45-P340). Human SynCAM shares 99% amino acid (aa) sequence identity with mouse SynCAM.
Isotype	Rabbit IgG
Molecular Weight	49 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cell adhesion molecule 1;Immunoglobulin superfamily member 4;IgSF4;Nectin-like protein 2;NECL-2;Spermatogenic immunoglobulin superfamily;SgIgSF;Synaptic cell adhesion molecule;SynCAM;Tumor suppressor in lung cancer 1;TSLC-1;CADM1 ;IGSF4 , IGSF4A, NECL2 , SYNCAM , TSLC1 ;
Tissue Specificity	Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9BY67
Gene Id	23705
Gene Name	CADM1
Sequence	Belongs to the nectin family.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Biederer, T., Sara, Y., Mozhayeva, M., Atasoy, D., Liu, X., Kavalali, E. T., Sudhof, T. C.SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297: 1525-1531, 2002. 2. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics 62 (2): 13946. 3. Yageta, Mika; Kuramochi Masami, Masuda Mari, Fukami Takeshi, Fukuhara Hiroshi, Maruyama Tomoko, Shibuya Masabumi, Murakami Yoshinori (Sep 2002). " association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. (United States) 62 (18): 512933.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000038-1	PB9136	100 ug	-	$370		Add to Cart
BHA21000038-3	PB9136-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000038-4	PB9136-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000038-5	PB9136-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000038-6	PB9136-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000038-7	PB9136-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000038-8	PB9136-FITC	100 ug	FITC	$570		Add to Cart
BHA21000038-9	PB9136-HRP	100 ug	HRP	$570		Add to Cart
BHA21000038-10	PB9136-APC	100 ug	APC	$670		Add to Cart
BHA21000038-11	PB9136-PE	100 ug	PE	$670		Add to Cart
BHA21000038-12	PB9136-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000038-13	PB9136-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000038-2	PB9136-10ug	10 ug	Sample	$99		Add to Cart

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