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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Survivin

SKU : BHA15100300

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BioGenex Laboratories

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Mfr.No.	AN826-5M
Clonality	Monoclonal
Description	Survivin belongs to inhibitor of apoptosis (IAP) protein family and it interferes with activation of caspases, other post-mitochondrial events. Survivin is expressed in most tumors, it regulates the cell cycle, but it is undetectable in heavily differentiated normal cells and tissues. Survivin expression occurs during G2/M phase of the cell cycle. During the intial stages of mitosis, survivin ineracts with microtubules of the mitotic spindle apparatus and that is heavily regulated by microtubule dynamics. Survivins anti-apoptotic activity is lost by disruption of survivin-microtubule interactions, it results in increase caspase-3 activity subsequent cell death during mitosis. Survivins nuclear-cytoplasmic shuttling is controlled by nuclear export signal (NES), it is necessary for the anti-apoptotic function of survivin. Inhibition of the NES makes cells more susceptible to chemotherapy- or radiotherapy-induced apoptosis. The interrelation of survivin expression with tumor progression is controversial, A recent study indicated nucelar survivin involved in promoting cell proliferation in most (if not all) cases, whereas the cytoplasmic pool of survivin may participate in controlling cell survival but not cell proliferation
Host	Rabbit
Isotype	IgG
Reactivity	Human
Species	Rabbit

Clone No	EP119
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-50

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AN826-5M	AN826-5M	6 mL	$229		Add to Cart
AN826-10M	AN826-10M	100 tests - i6000	$407		Add to Cart
AY826-50D	AY826-50D	50 tests - Xmatrx	$242		Add to Cart
AY826-YCD	AY826-YCD	160 tests - Xmatrx	$713		Add to Cart
NU826-UC	NU826-UC	1ml Conc	$480		Add to Cart
NU826-5UC	NU826-5UC	0.5ml Conc	$336		Add to Cart

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