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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SOCS3 Antibody Picoband®

SKU : BHA21006997

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Mfr.No.	PA1707, PA1707-10ug, PA1707-Biotin, PA1707-Cy3, PA1707-Dylight488, PA1707-Dylight550, PA1707-Dylight594, PA1707-FITC, PA1707-HRP, PA1707-APC, PA1707-PE, PA1707-iFluor647, PA1707-carrier-free
Alternative Names	Suppressor of cytokine signaling 3
Background	SOCS3 (Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene. SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SOCS3 Antibody catalog # PA1707. Tested in IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by bi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SOCS3, identical to the related mouse sequence, different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Suppressor of cytokine signaling 3;SOCS-3;Cytokine-inducible SH2 protein 3;CIS-3;STAT-induced STAT inhibitor 3;SSI-3;SOCS3;CIS3, SSI3;
Tissue Specificity	Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O14543
Gene Name	SOCS3
Sequence	Contains 1 SH2 domain.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. function as homooligomeric forms (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse<br>

Reference	1. Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., Nicholson, S. E., Norton, R. S.The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.Molec. Cell 22: 205-216, 2006.<br /><br />2. Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B.-M., Tato, C., Yoshimura, A., Hennighausen, L., O'Shea, J. J.Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.Proc. Nat. Acad. Sci. 103: 8137-8142, 2006.<br /><br />3. Jo, D., Liu, D., Yao, S., Collins, R. D., Hawiger, J.Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.Nature Med. 11: 892-898, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006997-1	PA1707	-	100 ug	$370		Add to Cart
BHA21006997-2	PA1707-10ug	Sample	10 ug	$99		Add to Cart
BHA21006997-3	PA1707-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006997-4	PA1707-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006997-5	PA1707-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006997-6	PA1707-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006997-7	PA1707-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006997-8	PA1707-FITC	FITC	100 ug	$570		Add to Cart
BHA21006997-9	PA1707-HRP	HRP	100 ug	$570		Add to Cart
BHA21006997-10	PA1707-APC	APC	100 ug	$670		Add to Cart
BHA21006997-11	PA1707-PE	PE	100 ug	$670		Add to Cart
BHA21006997-12	PA1707-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006997-13	PA1707-carrier-free	carrier-free	100 ug	$370		Add to Cart

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