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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SNAP25 Antibody Picoband®

SKU : BHA21006711

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Mfr.No.	PA1315, PA1315-10ug, PA1315-Biotin, PA1315-Cy3, PA1315-Dylight488, PA1315-Dylight550, PA1315-Dylight594, PA1315-FITC, PA1315-HRP, PA1315-APC, PA1315-PE, PA1315-iFluor647, PA1315-carrier-free
Alternative Names	Synaptosomal-associated protein 25
Background	Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids. It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus. The tSNARE (the target-membrane soluble NSF-attachment protein receptor, where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25 kDa (SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E (BoNT/E) abolishes stimulated secretion of insulin. In the nervous system, two SNAP-25 isoforms (a and b) have been described, which are produced by alteative splicing. Nagy et al. (2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A, a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles. SNAP-25 inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SNAP25 Antibody catalog # PA1315. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP25, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	40-50 kDa, 80-140 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Synaptosomal-associated protein 25;SNAP-25;Super protein;SUP;Synaptosomal-associated 25 kDa protein;SNAP25;SNAP;
Tissue Specificity	Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P60880
Gene Name	SNAP25
Sequence	Belongs to the SNAP-25 family.
Subcellular Location	Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor. Cell junction, synapse, synaptosome. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, Human, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Rat, Human, Mouse<br>

Reference	1. Gonelle-Gispert, C.; Halban, P. A.; Niemann, H.; Palmer, M.; Catsicas, S.; Sadoul, K. : SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion. Biochem. J. 339: 159-165, 1999. <br /><br />2. Nagy, G.; Reim, K.; Matti, U.; Brose, N.; Binz, T.; Rettig, J.; Neher, E.; Sorensen, J. B. : Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron 41: 417-429, 2004. <br /><br />3. Hodel A (1998). "SNAP-25". The Inteational Joual of Biochemistry & Cell Biology 30 (10): 10691073.<br /><br />4. Chapman ER (2002). "Synaptotagmin: A Ca2+ sensor that triggers exocytosis ". Nature Reviews Molecular Cell Biology 3: 498508.<br /><br />5. Pozzi D, Verderio C, Patti L, Grumelli C, Inverardi F, Frassoni C, Bonanno G, Matteoli M (2004). "SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization". Neuron 41 (4): 599610.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006711-1	PA1315	-	100 ug	$370		Add to Cart
BHA21006711-2	PA1315-10ug	Sample	10 ug	$99		Add to Cart
BHA21006711-3	PA1315-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006711-4	PA1315-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006711-5	PA1315-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006711-6	PA1315-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006711-7	PA1315-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006711-8	PA1315-FITC	FITC	100 ug	$570		Add to Cart
BHA21006711-9	PA1315-HRP	HRP	100 ug	$570		Add to Cart
BHA21006711-10	PA1315-APC	APC	100 ug	$670		Add to Cart
BHA21006711-11	PA1315-PE	PE	100 ug	$670		Add to Cart
BHA21006711-12	PA1315-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006711-13	PA1315-carrier-free	carrier-free	100 ug	$370		Add to Cart

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