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Home / Primary Antibodies

Anti-Smad2 (Ab-220) Antibody

SKU : BHA10916036

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y021323
Categories	Primary Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Host	Rabbit
Immunogen	The antibody was produced against synthesized non-phosphopeptide derived from human Smad2 around the phosphorylation site of threonine 220 (P-E-TP-P-P).
Isotype	IgG
Quantity	100 µg
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	Rabbit IgG in phosphate buffered saline (without Mg²+ and Ca²+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	100µg/100ul
Description	Specificity: Smad2 (Ab-220) Antibody detects endogenous levels of total Smad2 protein.
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC

Description

WB: 1:500~1:1000 IHC: 1:50~1:100, WB ; IHC

Dilution

WB	1:500-1:1000~
IHC	1:50-1:100~

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916036	Y021323	100 ug	$427.50		Add to Cart

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