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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SLUG/SNAI2 Antibody Picoband®

SKU : BHA21000334

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Mfr.No.	PB9439, PB9439-10ug, PB9439-Biotin, PB9439-Cy3, PB9439-Dylight488, PB9439-Dylight550, PB9439-Dylight594, PB9439-FITC, PB9439-HRP, PB9439-APC, PB9439-PE, PB9439-iFluor647, PB9439-carrier-free
Alternative Names	Zinc finger protein SNAI2
Background	SLUG is also known as SNAI2. This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Clonality	Polyclonal
Cross Reactivity	No cross reactivity with other proteins
Description	Boster Bio Anti-SLUG/SNAI2 Antibody Picoband® catalog # PB9439. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCL
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SLUG, identical to the related mouse and rat sequences.
Molecular Weight	30 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Zinc finger protein SNAI2;Neural crest transcription factor Slug;Protein snail homolog 2;SNAI2;SLUG, SLUGH;
Tissue Specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O43623
Gene Id	6591
Gene Name	SNAI2
Sequence	Belongs to the snail C2H2-type zinc-finger protein family.
Subcellular Location	Nucleus. Cytoplasm. Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Rat, By Heat

Reference	1. "Entrez Gene: SNAI2 snail homolog 2 (Drosophila) 2. Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S, Jabs EW (Oct 1998). "Human SLUG gene organization, expression, and chromosome map location on 8q". Genomics 51 (3): 46871. 3. Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ (Jan 1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8". Mamm Genome 8 (11): 8723.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000334-1	PB9439	100 ug	-	$370		Add to Cart
BHA21000334-2	PB9439-10ug	10 ug	Sample	$99		Add to Cart
BHA21000334-3	PB9439-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000334-4	PB9439-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000334-5	PB9439-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000334-6	PB9439-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000334-7	PB9439-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000334-8	PB9439-FITC	100 ug	FITC	$570		Add to Cart
BHA21000334-9	PB9439-HRP	100 ug	HRP	$570		Add to Cart
BHA21000334-10	PB9439-APC	100 ug	APC	$570		Add to Cart
BHA21000334-11	PB9439-PE	100 ug	PE	$570		Add to Cart
BHA21000334-12	PB9439-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000334-13	PB9439-carrier-free	100 ug	carrier-free	$370		Add to Cart

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