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Home / Primary Antibodies / IHC Antibodies

Anti-SLC2A1 Antibody BHA11300323

SKU : BHA11300323

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Mfr.No.	BS1149
Alternative Names	GLUT1 ; Glucose transporter type 1. erythrocyte/brain ; GLUT-1 ; GT1 ; Slc2a1 ; Glut-1 ; Glut1
Categories	Primary Antibodies
Chromosome Location	1p34.2
Clonality	polyclonal
Description	Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve pass transmembrane proteins (12TM) whose carboxytermini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 441-490 of Human Glut 1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P11166
Uniprot	P11166
Weight	54 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: GLUT1(G470) polyclonal antibody detects endogenous levels of GLUT1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300323	BS1149	50µl	$190.44		Add to Cart
BHA11300323	BS1149	100µl	$294.44		Add to Cart

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