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Home / Antibodies

Anti-Shc1 (Phospho-Tyr349) Antibody

SKU : BHA10918400

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y011316
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Host	Rabbit
Immunogen	The antibody was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 349 (H-Q-YP-Y-N).
Isotype	IgG
Quantity	100 µg
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	Rabbit IgG in phosphate buffered saline (without Mg²+ and Ca²+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	100µg/100ul
Description	Specificity: Shc1 (Phospho-Tyr349) antibody detects endogenous levels of Shc1 only when phosphorylated at tyrosine 349.
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IF

Description

WB: 1:500~1:1000 IF:1:100~1:200, WB ; IF

Dilution

WB	1:500-1:1000~
IF	1:100-1:200~

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SKU	Supplier No.	Size	Your price	Quantity
BHA10918400	Y011316	100 ug	$427.50		Add to Cart

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