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Home / Primary Antibodies

Anti-Shc1 (Ab-427) Antibody

SKU : BHA10916093

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y021317
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Host	Rabbit
Immunogen	The antiserum was produced against synthesized non-phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 427 (P-S-YP-V-N).
Quantity	100 µg
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1µg/ul
Description	Specificity: Shc1 (Ab-427) antibody detects endogenous levels of total Shc1 protein.
Format	Liquid
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC

Description

WB: 1:500~1:1000; IHC: 1:50~1:100, WB ; IHC

Dilution

WB	1:500-1:1000~
IHC	1:50-1:100~

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916093	Y021317	100 ug	$427.50		Add to Cart

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