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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Serotonin transporter/SLC6A4 Antibody Picoband®

SKU : BHA21006995

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Mfr.No.	PA1705, PA1705-10ug, PA1705-Biotin, PA1705-Cy3, PA1705-Dylight488, PA1705-Dylight550, PA1705-Dylight594, PA1705-FITC, PA1705-HRP, PA1705-APC, PA1705-PE, PA1705-iFluor647, PA1705-carrier-free
Alternative Names	Sodium-dependent serotonin transporter
Background	SLC6A4 (Solute carrier family 6, member 4), also known as SERT (serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Serotonin transporter/SLC6A4 Antibody catalog # PA1705. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key r
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium-dependent serotonin transporter;5HT transporter;5HTT;Solute carrier family 6 member 4;SLC6A4;HTT, SERT;
Tissue Specificity	Expressed in platelets (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P31645
Gene Name	SLC6A4
Sequence	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Kim, S.-J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., Guter, S., Leventhal, B. L., Courchesne, E., Cook, E. H., Jr.Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder.Molec. Psychiat. 7: 278-288, 2002.<br /><br />2. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., Murphy, D. L.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.Science 274: 1527-1530, 1996.<br /><br />Shen, S., Battersby, S., Weaver, M., Clark, E., Stephens, K., Harmar, A. J.Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.Europ. J. Hum. Genet. 8: 75-78, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006995-1	PA1705	-	100 ug	$370		Add to Cart
BHA21006995-2	PA1705-10ug	Sample	10 ug	$99		Add to Cart
BHA21006995-3	PA1705-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006995-4	PA1705-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006995-5	PA1705-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006995-6	PA1705-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006995-7	PA1705-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006995-8	PA1705-FITC	FITC	100 ug	$570		Add to Cart
BHA21006995-9	PA1705-HRP	HRP	100 ug	$570		Add to Cart
BHA21006995-10	PA1705-APC	APC	100 ug	$670		Add to Cart
BHA21006995-11	PA1705-PE	PE	100 ug	$670		Add to Cart
BHA21006995-12	PA1705-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006995-13	PA1705-carrier-free	carrier-free	100 ug	$370		Add to Cart

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