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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SA2/STAG2 Antibody Picoband®

SKU : BHA21004941

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Mfr.No.	A03624-1, A03624-1-10ug, A03624-1-Biotin, A03624-1-Cy3, A03624-1-Dylight488, A03624-1-Dylight550, A03624-1-Dylight594, A03624-1-FITC, A03624-1-HRP, A03624-1-APC, A03624-1-PE, A03624-1-iFluor647, A03624-1-carrier-free
Alternative Names	protocadherin related 15
Background	Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SA2/STAG2 Antibody Picoband® catalog # A03624-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Host	Rabbit
Immunogen Region	E.coli-derived human SA2/STAG2 recombinant protein (Position: E750-M1175).
Isotype	Rabbit IgG
Molecular Weight	141 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Protocadherin-15; PCDH15; USH1F
Tissue Specificity	Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited patte of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q8N3U4
Gene Id	10735
Gene Name	STAG2
Subcellular Location	Cell membrane. Single-pass type I. membrane protein. Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Aoi, H., Lei, M., Mizuguchi, T., Nishioka, N., Goto, T., Miyama, S., Suzuki, T., Iwama, K., Uchiyama, Y., Mitsuhashi, S., Itakura, A., Takeda, S., Matsumoto, N. Nonsense variants in STAG2 result in distinct sex-dependent phenotypes. J. Hum. Genet. 64: 487-492, 2019. Note: Retraction: J. Hum. Genet. 65: 811 only, 2020. 2. Balbas-Martinez, C., Sagrera, A., Carrillo-de-Santa-Pau, E., Earl, J., Marquez, M., Vazquez, M., Lapi, E., Castro-Giner, F., Beltran, S., Bayes, M., Carrato, A., Cigudosa, J. C., and 21 others. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nature Genet. 45: 1464-1469, 2013. 3. Carramolino, L., Lee, B. C., Zaballos. A., Peled, A., Barthelemy, I., Shav-Tal, Y., Prieto, I., Carmi, P., Gothelf, Y., Gonzalez de Buitrago, G., Aracil, M., Marquez, G., Barbero, J. L., Zipori, D. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene 195: 151-159, 1997. Note: Erratum: Gene 206: 283 only, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004941-1	A03624-1	-	100 ug	$370		Add to Cart
BHA21004941-2	A03624-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21004941-3	A03624-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004941-4	A03624-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004941-5	A03624-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004941-6	A03624-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004941-7	A03624-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004941-8	A03624-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21004941-9	A03624-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21004941-10	A03624-1-APC	APC	100 ug	$670		Add to Cart
BHA21004941-11	A03624-1-PE	PE	100 ug	$670		Add to Cart
BHA21004941-12	A03624-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004941-13	A03624-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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