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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RMI2 Antibody Picoband®

SKU : BHA21002098

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Mfr.No.	A08685, A08685-10ug, A08685-Biotin, A08685-Cy3, A08685-Dylight488, A08685-Dylight550, A08685-Dylight594, A08685-FITC, A08685-HRP, A08685-APC, A08685-PE, A08685-iFluor647, A08685-carrier-free
Alternative Names	RecQ mediated genome instability 2
Background	RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted ly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90%. Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RMI2 Antibody Picoband® catalog # A08685. Tested in Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, lo
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human RMI2, which shares 96.3% and 92.6% amino acid (aa) sequence identity with mouse and rat RMI2, respectively.
Isotype	Rabbit IgG
Molecular Weight	19 kDa
Reactivity	Human, Mouse, Rat
Specificity	No cross reactivity with other proteins.
Synonyms	RecQ-mediated genome instability protein 2; hRMI2; BLM-associated protein of 18 kDa; BLAP18; RMI2; C16orf75
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q96E14
Gene Id	116028
Gene Name	RMI2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunocytochemistry, 0.5-1ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Hartz, P. A. Personal Communication. Baltimore, Md. 11/20/2008.<br /><br />2. Singh, T. R., Ali, A. M., Busygina, V., Raynard, S., Fan, Q., Du, C., Andreassen, P. R., Sung, P., Meetei, A. R. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev. 22: 2856-2868, 2008.<br /><br />3. Xu, D., Guo, R., Sobeck, A., Bachrati, C. Z., Yang, J., Enomoto, T., Brown, G. W., Hoatlin, M. E., Hickson, I. D., Wang, W. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev. 22: 2843-2855, 2008.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002098-1	A08685	-	100 ug	$370		Add to Cart
BHA21002098-2	A08685-10ug	Sample	10 ug	$99		Add to Cart
BHA21002098-3	A08685-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002098-4	A08685-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002098-5	A08685-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002098-6	A08685-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002098-7	A08685-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002098-8	A08685-FITC	FITC	100 ug	$570		Add to Cart
BHA21002098-9	A08685-HRP	HRP	100 ug	$570		Add to Cart
BHA21002098-10	A08685-APC	APC	100 ug	$670		Add to Cart
BHA21002098-11	A08685-PE	PE	100 ug	$670		Add to Cart
BHA21002098-12	A08685-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002098-13	A08685-carrier-free	carrier-free	100 ug	$370		Add to Cart

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