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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RIP140/NRIP1 Antibody Picoband®

SKU : BHA21000652

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Mfr.No.	RP1095, RP1095-10ug, RP1095-Biotin, RP1095-Cy3, RP1095-Dylight488, RP1095-Dylight550, RP1095-Dylight594, RP1095-FITC, RP1095-HRP, RP1095-APC, RP1095-PE, RP1095-iFluor647, RP1095-carrier-free
Alternative Names	Nuclear receptor-interacting protein 1
Background	Nuclear receptor-interacting protein 1 (NRIP1), also known as receptor-interacting protein 140 (RIP140), is a protein that in humans is encoded by the NRIP1 gene. It is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein is a key regulator which modulates transcriptional activity of a variety of transcription factors, including the estrogen receptor. RIP140 has an important role in regulating lipid and glucose metabolism, and regulates gene expression in metabolic tissues including heart, skeletal muscle, and liver. A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1 and caitine palmitoyltransferase 1b.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RIP140/NRIP1 Antibody catalog # RP1095. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/B
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human RIP140, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nuclear receptor-interacting protein 1;Nuclear factor RIP140;Receptor-interacting protein 140;NRIP1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P48552
Gene Id	8204
Gene Name	NRIP1
Subcellular Location	Nucleus . Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human

Reference	1. Cavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG (Sep 1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor". EMBO J 14 (15): 374151. 2. Katsanis N, Ives JH, Groet J, Nizetic D, Fisher EM (Apr 1998). "Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome". Hum Genet102 (2): 2213. 3. Rosell M, Jones MC, Parker MG (2010). "Role of nuclear receptor corepressor RIP140 in metabolic syndrome.". Biochim Biophys Acta 1812(8): 91928.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000652-1	RP1095	100 ug	-	$370		Add to Cart
BHA21000652-2	RP1095-10ug	10 ug	Sample	$99		Add to Cart
BHA21000652-3	RP1095-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000652-4	RP1095-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000652-5	RP1095-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000652-6	RP1095-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000652-7	RP1095-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000652-8	RP1095-FITC	100 ug	FITC	$570		Add to Cart
BHA21000652-9	RP1095-HRP	100 ug	HRP	$570		Add to Cart
BHA21000652-10	RP1095-APC	100 ug	APC	$670		Add to Cart
BHA21000652-11	RP1095-PE	100 ug	PE	$670		Add to Cart
BHA21000652-12	RP1095-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000652-13	RP1095-carrier-free	100 ug	carrier-free	$370		Add to Cart

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