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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Ribonuclease 3/RNASE3 Antibody Picoband®

SKU : BHA21001793

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Mfr.No.	A03115-1, A03115-1-10ug, A03115-1-Biotin, A03115-1-Cy3, A03115-1-Dylight488, A03115-1-Dylight550, A03115-1-Dylight594, A03115-1-FITC, A03115-1-HRP, A03115-1-APC, A03115-1-PE, A03115-1-iFluor647, A03115-1-carrier-free
Alternative Names	ribonuclease A family member 3
Background	Eosinophil Cationic Protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene. The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are increased levels of ECP in the body.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Ribonuclease 3/RNASE3 Antibody Picoband® catalog # A03115-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positi
Host	Rabbit
Immunogen Region	E. coli-derived human Ribonuclease 3 recombinant protein (Position: R28-I160).
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Eosinophil cationic protein; ECP; Ribonuclease 3; RNase 3; RNASE3; ECP; RNS3
Tissue Specificity	Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P12724
Gene Id	6037
Gene Name	RNASE3
Subcellular Location	Secreted. Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (May 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 2402.<br /><br />2. Rosenberg, H. F., Ackerman, S. J., Tenen, D. G. Human eosinophil cationic protein: molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity. J. Exp. Med. 170: 163-176, 1989.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001793-1	A03115-1	100 ug	-	$370		Add to Cart
BHA21001793-2	A03115-1-10ug	10 ug	Sample	$99		Add to Cart
BHA21001793-3	A03115-1-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001793-4	A03115-1-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001793-5	A03115-1-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001793-6	A03115-1-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001793-7	A03115-1-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001793-8	A03115-1-FITC	100 ug	FITC	$570		Add to Cart
BHA21001793-9	A03115-1-HRP	100 ug	HRP	$570		Add to Cart
BHA21001793-10	A03115-1-APC	100 ug	APC	$670		Add to Cart
BHA21001793-11	A03115-1-PE	100 ug	PE	$670		Add to Cart
BHA21001793-12	A03115-1-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001793-13	A03115-1-carrier-free	100 ug	carrier-free	$370		Add to Cart

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