Anti-RAR alpha Antibody

Mfr.No.	Y058256
Categories	Primary Antibodies
Cellular Localization	Cytoplasimic and Nuclear
Clonality	polyclonal
Description	Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).
Host	Rabbit
Immunogen	Rabbit polyclonalRAR alpha (1) antibody was raised against a 15 amino acid peptide from near the C terminal residues of human retinoic acid receptor alpha protein.
Isotype	IgG
Quantity	100 µl
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC, ELISA

Description

For research use only
Peptide ELISA titer: 1:40,000
Western blot analysis: 1:200-1000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end use., WB ; IHC ; ELISA

Dilution

ELISA	1:40,000
WB	1:200-1000
IHC	1:50-200

No Description Available.

Have you used this product?

Rate it now..!!

SKU	Supplier No.	Size	Your price	Quantity
BHA10903497	Y058256	100 ul	$217.50		Add to Cart

Anti-RAR alpha Antibody

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Anti-RAR alpha Antibody

Rate it now..!!