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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Ran Antibody Picoband® (monoclonal, 5D5)

SKU : BHA21002275

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Mfr.No.	M00204-1, M00204-1-10ug, M00204-1-Biotin, M00204-1-Cy3, M00204-1-Dylight488, M00204-1-Dylight550, M00204-1-Dylight594, M00204-1-FITC, M00204-1-HRP, M00204-1-APC, M00204-1-PE, M00204-1-iFluor647, M00204-1-carrier-free
Alternative Names	RAN, member RAS oncogene family
Background	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in tu, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Ran Antibody Picoband® (monoclonal, 5D5) catalog # M00204-1. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear imp
Host	Mouse
Immunogen Region	E. coli-derived human Ran recombinant protein (Position: A2-L216). Human Ran shares 100% amino acid (aa) sequence identity with both mouse and rat Ran.
Isotype	Mouse IgG2b
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	GTP-binding nuclear protein Ran; Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein; RAN; ARA24; OK/SW-cl.81
Tissue Specificity	Expressed in a variety of tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P62826
Gene Id	5901
Gene Name	RAN
Clone No	Clone: 5D5
Subcellular Location	Cytosol. Nucleus. Nucleus envelope. Cytoplasm. Melanosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Avis JM, Clarke PR (October 1996). "Ran, a GTPase involved in nuclear processes: its regulators and effectors". J. Cell. Sci. 109 (10): 24237.<br /><br />2. Ciciarello M, Mangiacasale R, Lavia P (August 2007). "Spatial control of mitosis by the GTPase Ran". Cell. Mol. Life Sci. 64 (15): 1891914.<br /><br />3. Moore MS, Blobel G (May 1994). "A G protein involved in nucleocytoplasmic transport: the role of Ran". Trends Biochem. Sci. 19 (5): 2116.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002275-1	M00204-1	-	100 ug	$370		Add to Cart
BHA21002275-2	M00204-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002275-3	M00204-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002275-4	M00204-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002275-5	M00204-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002275-6	M00204-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002275-7	M00204-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002275-8	M00204-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002275-9	M00204-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002275-10	M00204-1-APC	APC	100 ug	$670		Add to Cart
BHA21002275-11	M00204-1-PE	PE	100 ug	$670		Add to Cart
BHA21002275-12	M00204-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002275-13	M00204-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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