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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RAGE/AGER Antibody Picoband®

SKU : BHA21003910

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Mfr.No.	A03438-1, A03438-1-10ug, A03438-1-Biotin, A03438-1-Cy3, A03438-1-Dylight488, A03438-1-Dylight550, A03438-1-Dylight594, A03438-1-FITC, A03438-1-HRP, A03438-1-APC, A03438-1-PE, A03438-1-iFluor647, A03438-1-carrier-free
Alternative Names	Tumor necrosis factor-inducible gene 6 protein
Background	The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. And RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RAGE/AGER Antibody Picoband® catalog # A03438-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
Host	Rabbit
Immunogen Region	E.coli-derived human RAGE/AGER recombinant protein (Position: K43-P404).
Isotype	Rabbit IgG
Molecular Weight	45-58 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Tumor necrosis factor-inducible gene 6 protein;Hyaluronate-binding protein;TNF-stimulated gene 6 protein;TSG-6;Tumor necrosis factor alpha-induced protein 6;TNF alpha-induced protein 6;TNFAIP6;TSG6;
Tissue Specificity	Found in the synovial fluid of patients with rheumatoid arthritis. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q15109
Gene Id	177
Gene Name	AGER
Subcellular Location	Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundorfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Ste DM, Aold B, Nawroth PP. Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest. 2004 Dec; 114(12):1741-51. 2. Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Aold B, Preissner KT, Nawroth PP. The patte recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J Exp Med. 2003 Nov 17; 198(10):1507-15. 3. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Ste D, Schmidt AM. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25; 97(7):889-901. 4. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Ste DM, Schmidt AM. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature.2000 May 18; 405(6784):354-60.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003910-1	A03438-1	-	100 ug	$370		Add to Cart
BHA21003910-2	A03438-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003910-3	A03438-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003910-4	A03438-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003910-5	A03438-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003910-6	A03438-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003910-7	A03438-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003910-8	A03438-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003910-9	A03438-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003910-10	A03438-1-APC	APC	100 ug	$670		Add to Cart
BHA21003910-11	A03438-1-PE	PE	100 ug	$670		Add to Cart
BHA21003910-12	A03438-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003910-13	A03438-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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