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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PTGIS/PGIS Antibody Picoband®

SKU : BHA21003883

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Mfr.No.	A05053-2, A05053-2-10ug, A05053-2-Biotin, A05053-2-Cy3, A05053-2-Dylight488, A05053-2-Dylight550, A05053-2-Dylight594, A05053-2-FITC, A05053-2-HRP, A05053-2-APC, A05053-2-PE, A05053-2-iFluor647, A05053-2-carrier-free
Alternative Names	musashi RNA binding protein 1
Background	Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PTGIS/PGIS Antibody Picoband® catalog # A05053-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the patte 5'-(GA)U1-3A
Host	Rabbit
Immunogen Region	E.coli-derived human PTGIS/PGIS recombinant protein (Position: D119-D470).
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	RNA-binding protein Musashi homolog 1; Musashi-1; MSI1
Tissue Specificity	Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q16647
Gene Id	5740
Gene Name	PTGIS
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Chevalier, D., Cauffiez, C., Beard, C., Lo-Guidice, J.-M., Allorge, D., Fazio, F., Ferrari, N., Libersa, C., Lhermitte, M., D'Halluin, J.-C., Broly, F. Characterization of new mutations in the coding sequence and 5-prime-untranslated region of the human prostacyclin synthase gene (CYP8A1). Hum. Genet. 108: 148-155, 2001. 2. Miyata, A., Hara, S., Yokoyama, C., Inoue, H., Ullrich, V., Tanabe, T. Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200: 1728-1734, 1994. 3. Nakayama, T., Soma, M., Watanabe, Y., Hasimu, B., Sato, M., Aoi, N., Kosuge, K., Kanmatsuse, K., Kokubun, S., Marrow, J. D., Oates, J. A. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem. Biophys. Res. Commun. 297: 1135-1139, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003883-1	A05053-2	-	100 ug	$370		Add to Cart
BHA21003883-2	A05053-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003883-3	A05053-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003883-4	A05053-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003883-5	A05053-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003883-6	A05053-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003883-7	A05053-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003883-8	A05053-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003883-9	A05053-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003883-10	A05053-2-APC	APC	100 ug	$670		Add to Cart
BHA21003883-11	A05053-2-PE	PE	100 ug	$670		Add to Cart
BHA21003883-12	A05053-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003883-13	A05053-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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