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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Prostacyclin Receptor (PTGIR) (extracellular) Antibody

SKU : BHA21301140

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Mfr.No.	APR-068, APR-068-CF_0.2 ml, APR-068_0.2 ml, APR-068_25 mcl, APR-068_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Prostaglandins comprise a family of locally acting hormones, whose synthesis is initiated by the enzyme COX. This pathway is involved in a broad variety of pathological conditions such as cancer, inflammation and hypertension.Prostaglandin I2 receptor (PGI2 receptor) is G-coupled protein receptor (GPCR) with seven hydrophobic transmembrane segments and an extracellular NH2 terminus. Prostaglandin receptors belong to family A, group V of GPCRs. There is significant ligand-binding cross-reactivity between different prostaglandins and different receptors in the family. Within the PG family, receptors share roughly 20-30% of their sequence and there are 34 identical residues across the family. Twenty of these residues are unique to PG receptors and are not shared by other GPCRs. The unique residues reside mostly in the transmembrane region and in the second extracellular loop region. Both of these regions are implicated in ligand binding. The PGI2 receptor signals primarily via stimulation of cAMP generation but through PIP2 as well despite a much higher agonist concentration required for PIP2 hydrolysis.PGI2 receptor mRNA is highly expressed in the human heart, aorta, kidney, liver and lung tissues and in mice thymus, heart and spleen1. Mice lacking PGI2 receptor have been shown to have a reduced inflammation response and a significant decrease in clinical arthritis. In addition, human patients with a dysfunctional PGI2 receptor variant exhibit an enhanced atherothrombotic phenotype with higher incidence of triple vessel coronary disease and cardiovascular events2.
Clonality	Polyclonal
Description	Anti-Prostacyclin Receptor (PTGIR) (extracellular) Antibody (#APR-068) is a highly specific antibody directed against an extracellular epitope of the rat PGI2 receptor. The antibody can be used in western blot and live cell flow cytometry applications. It has been designed to recognize PGI2 receptor from mouse, rat and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	3rd extracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor
UNSPSC Code	41116161
Note	Homology: Mouse - identical; human - 11/13 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PR068 Specifictiy: PTGIR Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P43253
Gene Id	292661
Target	Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor
Sequence	(C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat PTGIR

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IFC, LCI, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301140-1	APR-068-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301140-2	APR-068_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301140-3	APR-068_25 mcl	25 mcl	$597		Add to Cart
BHA21301140-4	APR-068_50 mcl	50 mcl	$697		Add to Cart

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